Vascular Signaling by Free Radicals Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress
نویسندگان
چکیده
J. Scott McNally,1,3 Michael E. Davis,1,3 Don P. Giddens,2 Aniket Saha,1,2 Jinah Hwang,1,2 Sergey Dikalov,1 Hanjoong Jo,1,2 and David G. Harrison1,3 1Division of Cardiology, 2Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, and 3Molecular and Systems Pharmacology Program, Emory University, Atlanta, 30322; and the Atlanta Veterans Hospital Medical Center, Decatur, Georgia 30033
منابع مشابه
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress.
Oscillatory shear stress occurs at sites of the circulation that are vulnerable to atherosclerosis. Because oxidative stress contributes to atherosclerosis, we sought to determine whether oscillatory shear stress increases endothelial production of reactive oxygen species and to define the enzymes responsible for this phenomenon. Bovine aortic endothelial cells were exposed to static, laminar (...
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Arterial regions exposed to oscillatory shear (OS) in branched arteries are lesion-prone sites of atherosclerosis, whereas those of laminar shear (LS) are relatively well protected. Here, we examined the hypothesis that OS and LS differentially regulate production of O2- from the endothelial NAD(P)H oxidase, which, in turn, is responsible for their opposite effects on a critical atherogenic eve...
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